Fractional CRO vs full-time CRO for a Series B company in 2027?

Direct Answer
Series B company: fractional vs full-time CRO
For most companies at this stage, fractional wins — you get a sitting-CRO operator 1–3 days/week without the $300k+ salary, equity grant, or 3-month ramp. Move to full-time only once revenue leadership is genuinely a 5-day-a-week job.

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The smart path
Start fractional, prove value in a paid pilot, and convert to interim or a full-time search when you've outgrown it.
