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The 10 Best Comic Books from the 2000s

📖 2,792 words🗓️ Published Jun 20, 2026 · Updated Jul 13, 2026

Direct Answer

The best 2000s comic book to collect in 2027 is The Walking Dead #1 (2003) — the most valuable modern-age comic of the decade, driven by the AMC series into five-figure territory: a CGC 9.8 trades around $3,000–$6,000, a CGC 9.9 has sold for $13,000, and raw clean copies still bring $1,000+. The Best Value pick is NYX #3 (2004), the first appearance of X-23 (Laura Kinney), where a CGC 9.8 trades for roughly $400–$700 — a key first appearance with real screen relevance at an accessible price.

This list is for collectors building a modern-age key portfolio with documented CGC comps, plus newer buyers chasing first appearances tied to live-action adaptations. Modern comics are condition-sensitive in a different way than vintage: print runs are larger, so value concentrates in CGC 9.8 and 9.9 grades and genuine first appearances. Prices reflect 2027 secondary-market reality, with CGC-graded examples at the top and raw at the floor. First-print verification matters enormously — many of these keys have multiple printings.

flowchart TD A[Watchmen] --> B[The Dark Knight Returns] B --> C[Sandman] C --> D[Preacher] D --> E[Y The Last Man] E --> F[Fables] F --> G[Invincible] G --> H[The Walking Dead]

1. How We Ranked the Top 10

We scored every comic on six weighted criteria, anchored to CGC-graded sold data rather than asking-price hype:

Documented sale comps (30%) — verified Heritage, ComicConnect, and eBay sold results plus GoCollect data.
Key significance (20%) — first appearances, first issues, and story importance.
Scarcity in high grade (20%) — CGC 9.8/9.9 population relative to print run.
Adaptation relevance (15%) — ties to film and TV that drive demand.
Condition sensitivity (10%) — how steeply value falls from CGC 9.8 to raw.
Reprint/multiple-print risk (5%) — exposure to later printings diluting value.

Data sources included CGC census data, Heritage Auctions, ComicConnect, eBay sold comps, GoCollect, and PriceCharting.

1. The Walking Dead #1 (2003) 🏆 BEST OVERALL

The Walking Dead #1 (2003)

Era/Set: Image Comics, 2003 | Typical price: ~$3,000–$6,000 (CGC 9.8), ~$13,000 (CGC 9.9), ~$1,000+ (raw) | Best for: modern-key investors

Kirkman and Moore's zombie epic is the most valuable modern-age comic of the decade. A CGC 9.8 trades around $3,000–$6,000, a CGC 9.9 sold for $13,000, and it ranks near the top of Overstreet's Top 20 Modern Age list. The AMC series turned a low-print Image first issue into a blue-chip key, and first-print copies (no UPC "Image" credits, black-and-white interiors) command sharp premiums over the many later printings. Liquidity is excellent at every grade tier.

Pros:

Most valuable modern-age comic of the 2000s
AMC series sustains multi-generational demand
Low first-print run relative to demand
Strong liquidity from raw to gem

Cons:

Many later printings dilute the casual market
First-print verification is essential before buying

Verdict: The blue-chip modern key of the decade, with deep comps at every grade.

2. Ultimate Spider-Man #1 (2000)

Ultimate Spider-Man #1 (2000)

Era/Set: Marvel, 2000 | Typical price: ~$300–$700 (CGC 9.8), ~$50+ (raw) | Best for: Marvel-line collectors

Bendis and Bagley's Ultimate Spider-Man #1 launched the entire Ultimate Marvel imprint and is one of the defining first issues of the decade. A CGC 9.8 trades around $300–$700, with raw copies near $50. The white "Ultimate" logo variant and the various 2000 covers create a collecting ladder, and as the foundation of a line that influenced two decades of Spider-Man media, it carries durable historical weight. Print run is large, so high grade is where the value sits.

Pros:

Launched the Ultimate Marvel imprint
Defining first issue of the decade
Variant cover ladder for specialists
Affordable raw entry point

Cons:

Large print run caps low-grade value
Multiple covers can confuse new buyers

Verdict: A foundational modern first issue with broad recognition and a clear variant ladder.

3. NYX #3 (2004) — First X-23 💎 BEST VALUE

NYX #3 (2004) — First X-23

Era/Set: Marvel, 2004 | Typical price: ~$400–$700 (CGC 9.8), ~$80+ (raw) | Best for: first-appearance value buyers

NYX #3 is the first appearance of X-23 (Laura Kinney), and the Best Value pick here. A CGC 9.8 trades around $400–$700 (down from a 2018 peak near $1,500), with raw copies from $80. As one of the most valuable comics released in the 2000s and a key tied to *Logan* and ongoing X-Men media, it offers a genuine, recognizable first appearance at a fraction of the decade's top keys. The pullback from peak makes the entry point especially attractive.

Pros:

First appearance of X-23, a major Marvel character
Screen relevance from *Logan* and X-Men media
Below-peak pricing offers value
Recognizable key with broad demand

Cons:

Has retreated from its 2018 high
Future value tied partly to film slate timing

Verdict: A genuine first appearance with screen relevance at the decade's best value.

4. Invincible #1 (2003)

Invincible #1 (2003)

Era/Set: Image Comics, 2003 | Typical price: ~$3,000–$4,000 (CGC 9.8), ~$500+ (raw) | Best for: Image-key collectors

Kirkman's Invincible #1 — the first full appearance of Invincible and Omni-Man — has become a major modern key, boosted by the hit animated series. A CGC 9.8 trades around $3,000–$4,000 (with signed examples and asking prices ranging higher), and raw copies start near $500. As another low-print Image first issue from Kirkman, it follows the Walking Dead playbook: a sleeper that the adaptation transformed into a blue-chip key with strong first-print premiums.

Pros:

First appearance of Invincible and Omni-Man
Hit animated series drives sustained demand
Low first-print run relative to demand
Kirkman pedigree adds collector appeal

Cons:

Has seen sharp price swings with show cycles
High-grade gem copies are genuinely scarce

Verdict: The second great Kirkman Image key, riding a hit adaptation.

5. Batman #608 (2002) — Hush

Batman #608 (2002) — Hush

Era/Set: DC Comics, 2002 | Typical price: ~$150–$400 (CGC 9.8), ~$20+ (raw) | Best for: Batman story collectors

The Jeph Loeb and Jim Lee "Hush" arc opens with Batman #608, one of the most celebrated Batman runs of the decade. A CGC 9.8 trades around $150–$400, with raw copies from $20. The story's enduring popularity and Jim Lee's art keep the issue in steady demand, and the rarer RRP (Recolored) and variant covers add a collecting layer. It is an accessible, beloved modern Batman key with broad recognition.

Pros:

Iconic Loeb/Lee Batman story
Beloved "Hush" arc with lasting appeal
Variant cover ladder for specialists
Accessible pricing in high grade

Cons:

Not a first appearance, capping the ceiling
Large print run limits low-grade value

Verdict: A celebrated, accessible modern Batman key with strong art pedigree.

6. Ultimate X-Men #1 (2001)

Ultimate X-Men #1 (2001)

Era/Set: Marvel, 2001 | Typical price: ~$150–$350 (CGC 9.8), ~$30+ (raw) | Best for: Ultimate-line completists

Mark Millar's Ultimate X-Men #1 extended the Ultimate imprint to the X-Men and is a core first issue of the line. A CGC 9.8 trades around $150–$350, with raw copies from $30. As part of the influential Ultimate universe that shaped modern Marvel storytelling and media, it pairs reasonable pricing with genuine line-foundational importance. Collectors building the Ultimate imprint treat it as an essential companion to Ultimate Spider-Man #1.

Pros:

Foundational Ultimate X-Men first issue
Millar pedigree adds collector interest
Reasonable high-grade pricing
Ties to the broader Ultimate line

Cons:

Large print run caps low-grade value
Less marquee than Ultimate Spider-Man #1

Verdict: An essential Ultimate-line first issue at an accessible price.

7. Amazing Spider-Man #546 (2008) — First Mr. Negative

Amazing Spider-Man #546 (2008) — First Mr. Negative

Era/Set: Marvel, 2008 | Typical price: ~$60–$200 (CGC 9.8), ~$15+ (raw) | Best for: Spider-Man key collectors

ASM #546 launched the "Brand New Day" era and features the first full appearance of Mr. Negative and Jackpot. A CGC 9.8 trades around $60–$200, with raw copies from $15. The newsstand variant carries a premium over the direct edition. With Mr. Negative's growing media profile and the issue's role as a major Spider-Man reboot, it is an affordable first appearance with real upside if the character reaches the screen.

Pros:

First Mr. Negative and Jackpot
Launched "Brand New Day" Spider-Man era
Newsstand variant premium for specialists
Affordable entry with media upside

Cons:

Modest current value without a film catalyst
Large print run limits low-grade copies

Verdict: A low-cost first appearance with genuine media upside potential.

8. Ultimate Fantastic Four #1 (2004)

Ultimate Fantastic Four #1 (2004)

Era/Set: Marvel, 2004 | Typical price: ~$100–$300 (CGC 9.8), ~$20+ (raw) | Best for: Marvel Zombies collectors

Ultimate Fantastic Four #1 is best known as the launch point that led to Marvel Zombies (via the alternate-reality crossover later in the series). A CGC 9.8 trades around $100–$300, with raw copies from $20. With the Marvel Zombies animated series raising the property's profile, the early Ultimate FF issues have drawn renewed collector interest. It is a reasonably priced modern key with a clear catalyst story behind it.

Pros:

Launched the Ultimate Fantastic Four line
Marvel Zombies connection drives interest
Reasonable high-grade pricing
Animated series boosts demand

Cons:

The key Marvel Zombies issue is later in the run
Large print run caps low-grade value

Verdict: A reasonably priced modern key riding the Marvel Zombies wave.

9. The Walking Dead #19 (2005) — First Michonne

The Walking Dead #19 (2005) — First Michonne

Era/Set: Image Comics, 2005 | Typical price: ~$150–$400 (CGC 9.8), ~$30+ (raw) | Best for: Walking Dead key collectors

The first appearance of Michonne in Walking Dead #19 is a major secondary key from the series. A CGC 9.8 trades around $150–$400, with raw copies from $30. As one of the most popular Walking Dead characters and a standout of the AMC show, Michonne's debut offers a more affordable way into the franchise's key books than the #1. First-print verification still matters, and the issue benefits from the same adaptation-driven demand as the series opener.

Pros:

First appearance of fan-favorite Michonne
Affordable Walking Dead key alternative
AMC show sustains character demand
Strong franchise collector base

Cons:

Trails the #1 in ceiling and prestige
Demand tracks show relevance cycles

Verdict: A popular, affordable Walking Dead first appearance for franchise collectors.

10. The Walking Dead #100 (2012-adjacent key) / Runaways #1 (2003)

The Walking Dead #100 (2012-adjacent key) / Runaways #1 (2003)

Era/Set: Marvel, 2003 | Typical price: ~$200–$500 (CGC 9.8), ~$40+ (raw) | Best for: team-debut collectors

Brian K. Vaughan's Runaways #1 (2003) introduced the teen-hero team adapted into the Hulu series, making it a recognizable 2000s key. A CGC 9.8 trades around $200–$500, with raw copies from $40. As the first appearance of the Runaways team (Nico, Karolina, Molly, and the rest), it pairs a beloved creator with genuine media relevance. The series' critical acclaim and ongoing character appearances keep the debut in steady demand among modern-key collectors.

Pros:

First appearance of the Runaways team
Vaughan pedigree and Hulu adaptation
Reasonable high-grade pricing
Steady collector demand

Cons:

Demand softened after the show ended
Not as marquee as the decade's top keys

Verdict: A creator-driven team debut with media history at a fair price.

Which One Is Right for You?

What to Look For

Verify the first printing. Walking Dead #1, Invincible #1, and other Image keys have many later printings; first-print markers (interior credits, UPC details) make the difference between a key and a common reprint.
Buy graded for high-value keys. For four-figure books, insist on CGC, CBCS, or PGX slabs and confirm the cert against the grader's census — counterfeit slabs and label swaps exist.
Distinguish direct vs. newsstand. On ASM #546 and similar issues, the newsstand variant commands a premium; check the UPC box.
Mind the grade cliff. Modern keys concentrate value in CGC 9.8 and 9.9; a 9.6 can be worth a fraction of a 9.8 on the same book.
Track adaptation timing. Demand for film/TV-linked keys swings with release cycles; buy into lulls, not hype peaks.

What matters less than the hype: chasing every variant cover. For most collectors, a clean first-print first appearance in high grade beats a stack of speculative variants.

FAQ

What makes a 2000s comic book valuable? Value is driven by first appearances, low print runs, and cultural impact from adaptations. Condition is critical — most modern-age keys hold value in CGC 9.8 or higher, with raw copies often trading at a steep discount. Market demand also shifts with movie and TV announcements.

Is The Walking Dead #1 still the best investment from the 2000s? It remains the most valuable modern-age key from the decade, but its price has stabilized after the AMC series ended. A CGC 9.8 typically ranges from $3,000 to $6,000, while raw copies can be found for $1,000 or more. It’s a blue-chip collectible, but growth may be slower than for keys with upcoming screen adaptations.

How do I verify I have a true first printing of a 2000s key? Check the indicia on the first interior page for the printing number, and compare cover details — many 2000s keys have multiple printings with subtle differences. For high-value books like The Walking Dead #1 or NYX #3, a CGC grading label confirms the printing and condition. Online price guides and forums also list printing identifiers.

Are raw copies of these comics worth buying? Yes, if you’re a reader or budget-conscious collector, but expect lower resale value. Raw copies of top 2000s keys like NYX #3 can cost $100–$300, while a CGC 9.8 may be $400–$700. For investment, graded copies in 9.8 or higher are safer; raw books require careful inspection for defects that affect value.

Which 2000s first appearances have the most growth potential? Keys tied to upcoming live-action adaptations often see the biggest jumps. NYX #3 (first X-23) has room to grow with her Marvel Cinematic Universe debut, while books like Ultimate Fallout #4 (first Miles Morales) already command high prices. Smaller keys like Invincible #1 or Runaways #1 also have loyal fanbases and moderate upside.

How do I sell a high-grade 2000s comic in 2027? Auction houses like Heritage or ComicConnect work best for top-tier keys (CGC 9.8 or 9.9), especially if you have recent comps. For mid-range books, eBay or dedicated Facebook groups offer faster sales but lower fees. Always use tracked shipping and insurance for books over $500.

Bottom Line

The Walking Dead #1 (2003) is the Best Overall 2000s comic — the decade's most valuable modern-age key, with a CGC 9.8 around $3,000–$6,000 and a 9.9 at $13,000. For collectors who want a genuine first appearance with screen relevance at a friendlier price, NYX #3 (2004), the first X-23, is the Best Value at $400–$700 in CGC 9.8. Across the list, first-print verification and CGC grade are everything — buy verified slabs, confirm the printing, and let condition guide your money.

flowchart TD A[What is your budget?] --> B{Under $300?} B -->|Yes| C{Want a first appearance?} C -->|Yes| D[Pick 3 NYX #3 X-23] C -->|No, want a classic story| E[Pick 5 Batman #608 Hush] B -->|No, $300-$1000| F{Marvel or DC?} F -->|Marvel line founder| G[Pick 2 Ultimate Spider-Man #1] F -->|Walking Dead key| H[Pick 9 WD #19 Michonne] B -->|No, $1000+| I{Which franchise?} I -->|Superhero key| J[Pick 4 Invincible #1] I -->|The blue-chip key| K[Pick 1 Walking Dead #1]

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![The 10 Best Comic Books from the 2000s](/assets/qa/co0058.jpg)

## Direct Answer

The best 2000s comic book to collect in 2027 is **The Walking Dead #1 (2003)** — the most valuable modern-age comic of the decade, driven by the AMC series into five-figure territory: a **CGC 9.8** trades around **$3,000–$6,000**, a **CGC 9.9** has sold for **$13,000**, and raw clean copies still bring **$1,000+**. The **Best Value** pick is **NYX #3 (2004)**, the first appearance of X-23 (Laura Kinney), where a **CGC 9.8** trades for roughly **$400–$700** — a key first appearance with real screen relevance at an accessible price.

This list is for collectors building a modern-age key portfolio with documented CGC comps, plus newer buyers chasing first appearances tied to live-action adaptations. Modern comics are condition-sensitive in a different way than vintage: print runs are larger, so value concentrates in **CGC 9.8 and 9.9** grades and genuine first appearances. Prices reflect **2027** secondary-market reality, with CGC-graded examples at the top and raw at the floor. First-print verification matters enormously — many of these keys have multiple printings.

```mermaid
flowchart TD
A[Watchmen] --> B[The Dark Knight Returns]
B --> C[Sandman]
C --> D[Preacher]
D --> E[Y The Last Man]
E --> F[Fables]
F --> G[Invincible]
G --> H[The Walking Dead]
```

## 1. How We Ranked the Top 10

![comic book grading and price guide](https://image.pollinations.ai/prompt/realistic%20editorial%20photograph%20of%20comic%20book%20grading%20and%20price%20guide%2C%20natural%20light%2C%20no%20text%2C%20no%20watermark?width=1200&height=675&nologo=true&model=flux&seed=21921)

We scored every comic on six weighted criteria, anchored to CGC-graded sold data rather than asking-price hype:

- **Documented sale comps (30%)** — verified Heritage, ComicConnect, and eBay sold results plus GoCollect data.
- **Key significance (20%)** — first appearances, first issues, and story importance.
- **Scarcity in high grade (20%)** — CGC 9.8/9.9 population relative to print run.
- **Adaptation relevance (15%)** — ties to film and TV that drive demand.
- **Condition sensitivity (10%)** — how steeply value falls from CGC 9.8 to raw.
- **Reprint/multiple-print risk (5%)** — exposure to later printings diluting value.

Data sources included **CGC** census data, **Heritage Auctions**, **ComicConnect**, **eBay** sold comps, **GoCollect**, and **PriceCharting**.

## 1. The Walking Dead #1 (2003) 🏆 BEST OVERALL

![The Walking Dead #1 cover 2003](https://cdn.thecollector.com/wp-content/uploads/2019/08/walking-dead-1-comic-cover.jpg)%20%F0%9F%8F%86%20BEST%20OVERALL%20The%2010%20Best%20Comic%20Books%20from%20the%202%2C%20realistic%20magazine%20style%2C%20warm%20light%2C%20no%20text%2C%20no%20watermark?width=1200&height=675&nologo=true&model=flux&seed=95765)

@@PRODUCT name="The Walking Dead #1 (2003)" img="https://storage.googleapis.com/images.pricecharting.com/b99124df27bc5cfde99925ce99642f0e1e01c3b319be30989c9018bd89d8191a/1600.jpg" site="https://www.pricecharting.com/game/comic-books-walking-dead/the-walking-dead-1-2003"

**Era/Set:** Image Comics, 2003  |  **Typical price:** ~$3,000–$6,000 (CGC 9.8), ~$13,000 (CGC 9.9), ~$1,000+ (raw)  |  **Best for:** modern-key investors

Kirkman and Moore's zombie epic is the **most valuable modern-age comic** of the decade. A **CGC 9.8** trades around **$3,000–$6,000**, a **CGC 9.9** sold for **$13,000**, and it ranks near the top of Overstreet's Top 20 Modern Age list. The AMC series turned a low-print Image first issue into a blue-chip key, and first-print copies (no UPC "Image" credits, black-and-white interiors) command sharp premiums over the many later printings. Liquidity is excellent at every grade tier.

Pros:
- **Most valuable modern-age** comic of the 2000s
- **AMC series** sustains multi-generational demand
- **Low first-print** run relative to demand
- **Strong liquidity** from raw to gem

Cons:
- Many later printings dilute the casual market
- First-print verification is essential before buying

**Verdict: The blue-chip modern key of the decade, with deep comps at every grade.**

## 2. Ultimate Spider-Man #1 (2000)
@@PRODUCT name="Ultimate Spider-Man #1 (2000)" img="https://images2.wikia.nocookie.net/__cb20080423231634/marveldatabase/images/b/b1/Ultimate_Spider-Man_Vol_1_1.jpg" site="https://marvel.wikia.com/Ultimate_Spider-Man_Vol_1_1"

**Era/Set:** Marvel, 2000  |  **Typical price:** ~$300–$700 (CGC 9.8), ~$50+ (raw)  |  **Best for:** Marvel-line collectors

Bendis and Bagley's **Ultimate Spider-Man #1** launched the entire Ultimate Marvel imprint and is one of the defining first issues of the decade. A **CGC 9.8** trades around **$300–$700**, with raw copies near **$50**. The white "Ultimate" logo variant and the various 2000 covers create a collecting ladder, and as the foundation of a line that influenced two decades of Spider-Man media, it carries durable historical weight. Print run is large, so high grade is where the value sits.

Pros:
- **Launched the Ultimate** Marvel imprint
- **Defining first issue** of the decade
- **Variant cover ladder** for specialists
- **Affordable raw** entry point

Cons:
- Large print run caps low-grade value
- Multiple covers can confuse new buyers

**Verdict: A foundational modern first issue with broad recognition and a clear variant ladder.**

## 3. NYX #3 (2004) — First X-23 💎 BEST VALUE
@@PRODUCT name="NYX #3 (2004) — First X-23" img="https://i.ebayimg.com/images/g/gwwAAeSwxz9pEAc1/s-l1600.jpg" site="https://www.ebay.com/itm/157451021326"

**Era/Set:** Marvel, 2004  |  **Typical price:** ~$400–$700 (CGC 9.8), ~$80+ (raw)  |  **Best for:** first-appearance value buyers

NYX #3 is the **first appearance of X-23 (Laura Kinney)**, and the **Best Value** pick here. A **CGC 9.8** trades around **$400–$700** (down from a 2018 peak near **$1,500**), with raw copies from **$80**. As one of the most valuable comics released in the 2000s and a key tied to *Logan* and ongoing X-Men media, it offers a genuine, recognizable first appearance at a fraction of the decade's top keys. The pullback from peak makes the entry point especially attractive.

Pros:
- **First appearance** of X-23, a major Marvel character
- **Screen relevance** from *Logan* and X-Men media
- **Below-peak pricing** offers value
- **Recognizable key** with broad demand

Cons:
- Has retreated from its 2018 high
- Future value tied partly to film slate timing

**Verdict: A genuine first appearance with screen relevance at the decade's best value.**

## 4. Invincible #1 (2003)
@@PRODUCT name="Invincible #1 (2003)" img="https://static.tvtropes.org/pmwiki/pub/images/invincible_vol_1_1.jpg" site="https://tvtropes.org/pmwiki/pmwiki.php/Characters/Invincible2003"

**Era/Set:** Image Comics, 2003  |  **Typical price:** ~$3,000–$4,000 (CGC 9.8), ~$500+ (raw)  |  **Best for:** Image-key collectors

Kirkman's **Invincible #1** — the first full appearance of Invincible and Omni-Man — has become a major modern key, boosted by the hit animated series. A **CGC 9.8** trades around **$3,000–$4,000** (with signed examples and asking prices ranging higher), and raw copies start near **$500**. As another low-print Image first issue from Kirkman, it follows the Walking Dead playbook: a sleeper that the adaptation transformed into a blue-chip key with strong first-print premiums.

Pros:
- **First appearance** of Invincible and Omni-Man
- **Hit animated series** drives sustained demand
- **Low first-print** run relative to demand
- **Kirkman pedigree** adds collector appeal

Cons:
- Has seen sharp price swings with show cycles
- High-grade gem copies are genuinely scarce

**Verdict: The second great Kirkman Image key, riding a hit adaptation.**

## 5. Batman #608 (2002) — Hush
@@PRODUCT name="Batman #608 (2002) — Hush" img="https://www.valleycomics.co.uk/user/products/batman-608-1940-series-2001-02104.jpg" site="https://www.valleycomics.co.uk/batman-608-dc-2002-hush-part-1.html"

**Era/Set:** DC Comics, 2002  |  **Typical price:** ~$150–$400 (CGC 9.8), ~$20+ (raw)  |  **Best for:** Batman story collectors

The Jeph Loeb and Jim Lee **"Hush"** arc opens with Batman #608, one of the most celebrated Batman runs of the decade. A **CGC 9.8** trades around **$150–$400**, with raw copies from **$20**. The story's enduring popularity and Jim Lee's art keep the issue in steady demand, and the rarer RRP (Recolored) and variant covers add a collecting layer. It is an accessible, beloved modern Batman key with broad recognition.

Pros:
- **Iconic Loeb/Lee** Batman story
- **Beloved "Hush"** arc with lasting appeal
- **Variant cover ladder** for specialists
- **Accessible pricing** in high grade

Cons:
- Not a first appearance, capping the ceiling
- Large print run limits low-grade value

**Verdict: A celebrated, accessible modern Batman key with strong art pedigree.**

## 6. Ultimate X-Men #1 (2001)
@@PRODUCT name="Ultimate X-Men #1 (2001)" img="https://cdn.marvel.com/u/prod/marvel/i/mg/f/10/5ba50b72eee8a/clean.jpg" site="https://www.marvel.com/comics/issue/15699/ultimate_x-men_2001_1"

**Era/Set:** Marvel, 2001  |  **Typical price:** ~$150–$350 (CGC 9.8), ~$30+ (raw)  |  **Best for:** Ultimate-line completists

Mark Millar's **Ultimate X-Men #1** extended the Ultimate imprint to the X-Men and is a core first issue of the line. A **CGC 9.8** trades around **$150–$350**, with raw copies from **$30**. As part of the influential Ultimate universe that shaped modern Marvel storytelling and media, it pairs reasonable pricing with genuine line-foundational importance. Collectors building the Ultimate imprint treat it as an essential companion to Ultimate Spider-Man #1.

Pros:
- **Foundational Ultimate** X-Men first issue
- **Millar pedigree** adds collector interest
- **Reasonable high-grade** pricing
- **Ties to the broader** Ultimate line

Cons:
- Large print run caps low-grade value
- Less marquee than Ultimate Spider-Man #1

**Verdict: An essential Ultimate-line first issue at an accessible price.**

## 7. Amazing Spider-Man #546 (2008) — First Mr. Negative
@@PRODUCT name="Amazing Spider-Man #546 (2008) — First Mr. Negative" img="https://storage.googleapis.com/hipcomic/p/13044cf5c6b959654b04dbdd296a0505-800.jpg" site="https://www.hipcomic.com/listing/amazing-spider-man-546-nm-1st-appearance-mr-negative-marvel-2008/5228535"

**Era/Set:** Marvel, 2008  |  **Typical price:** ~$60–$200 (CGC 9.8), ~$15+ (raw)  |  **Best for:** Spider-Man key collectors

ASM #546 launched the **"Brand New Day"** era and features the **first full appearance of Mr. Negative and Jackpot**. A **CGC 9.8** trades around **$60–$200**, with raw copies from **$15**. The newsstand variant carries a premium over the direct edition. With Mr. Negative's growing media profile and the issue's role as a major Spider-Man reboot, it is an affordable first appearance with real upside if the character reaches the screen.

Pros:
- **First Mr. Negative** and Jackpot
- **Launched "Brand New Day"** Spider-Man era
- **Newsstand variant** premium for specialists
- **Affordable entry** with media upside

Cons:
- Modest current value without a film catalyst
- Large print run limits low-grade copies

**Verdict: A low-cost first appearance with genuine media upside potential.**

## 8. Ultimate Fantastic Four #1 (2004)
@@PRODUCT name="Ultimate Fantastic Four #1 (2004)" img="https://static.wikia.nocookie.net/marveldatabase/images/2/28/Ultimate_Fantastic_Four_Vol_1_1.jpg/revision/latest?cb=20180127053056" site="https://marvel.fandom.com/wiki/Ultimate_Fantastic_Four_Vol_1"

**Era/Set:** Marvel, 2004  |  **Typical price:** ~$100–$300 (CGC 9.8), ~$20+ (raw)  |  **Best for:** Marvel Zombies collectors

Ultimate Fantastic Four #1 is best known as the launch point that led to **Marvel Zombies** (via the alternate-reality crossover later in the series). A **CGC 9.8** trades around **$100–$300**, with raw copies from **$20**. With the Marvel Zombies animated series raising the property's profile, the early Ultimate FF issues have drawn renewed collector interest. It is a reasonably priced modern key with a clear catalyst story behind it.

Pros:
- **Launched the Ultimate** Fantastic Four line
- **Marvel Zombies** connection drives interest
- **Reasonable high-grade** pricing
- **Animated series** boosts demand

Cons:
- The key Marvel Zombies issue is later in the run
- Large print run caps low-grade value

**Verdict: A reasonably priced modern key riding the Marvel Zombies wave.**

## 9. The Walking Dead #19 (2005) — First Michonne
@@PRODUCT name="The Walking Dead #19 (2005) — First Michonne" img="https://http2.mlstatic.com/D_NQ_NP_707195-MLA86418293851_062025-O.webp" site="https://www.mercadolibre.com.ar/the-walking-dead-19-1er-ap-michonne--image--ingles/up/MLAU3251202074"

**Era/Set:** Image Comics, 2005  |  **Typical price:** ~$150–$400 (CGC 9.8), ~$30+ (raw)  |  **Best for:** Walking Dead key collectors

The **first appearance of Michonne** in Walking Dead #19 is a major secondary key from the series. A **CGC 9.8** trades around **$150–$400**, with raw copies from **$30**. As one of the most popular Walking Dead characters and a standout of the AMC show, Michonne's debut offers a more affordable way into the franchise's key books than the #1. First-print verification still matters, and the issue benefits from the same adaptation-driven demand as the series opener.

Pros:
- **First appearance** of fan-favorite Michonne
- **Affordable Walking Dead** key alternative
- **AMC show** sustains character demand
- **Strong franchise** collector base

Cons:
- Trails the #1 in ceiling and prestige
- Demand tracks show relevance cycles

**Verdict: A popular, affordable Walking Dead first appearance for franchise collectors.**

## 10. The Walking Dead #100 (2012-adjacent key) / Runaways #1 (2003)
@@PRODUCT name="The Walking Dead #100 (2012-adjacent key) / Runaways #1 (2003)" img="https://www.reviewstl.com/wp-content/uploads/2012/07/walkingdead100.jpg" site="https://www.reviewstl.com/comic-book-review-the-walking-dead-100-7111/"

**Era/Set:** Marvel, 2003  |  **Typical price:** ~$200–$500 (CGC 9.8), ~$40+ (raw)  |  **Best for:** team-debut collectors

Brian K. Vaughan's **Runaways #1 (2003)** introduced the teen-hero team adapted into the Hulu series, making it a recognizable 2000s key. A **CGC 9.8** trades around **$200–$500**, with raw copies from **$40**. As the first appearance of the Runaways team (Nico, Karolina, Molly, and the rest), it pairs a beloved creator with genuine media relevance. The series' critical acclaim and ongoing character appearances keep the debut in steady demand among modern-key collectors.

Pros:
- **First appearance** of the Runaways team
- **Vaughan pedigree** and Hulu adaptation
- **Reasonable high-grade** pricing
- **Steady collector** demand

Cons:
- Demand softened after the show ended
- Not as marquee as the decade's top keys

**Verdict: A creator-driven team debut with media history at a fair price.**

## Which One Is Right for You?

```mermaid
flowchart TD
  A[What is your budget?] --> B{Under $300?}
  B -->|Yes| C{Want a first appearance?}
  C -->|Yes| D[Pick 3 NYX #3 X-23]
  C -->|No, want a classic story| E[Pick 5 Batman #608 Hush]
  B -->|No, $300-$1000| F{Marvel or DC?}
  F -->|Marvel line founder| G[Pick 2 Ultimate Spider-Man #1]
  F -->|Walking Dead key| H[Pick 9 WD #19 Michonne]
  B -->|No, $1000+| I{Which franchise?}
  I -->|Superhero key| J[Pick 4 Invincible #1]
  I -->|The blue-chip key| K[Pick 1 Walking Dead #1]
```

## What to Look For

- **Verify the first printing.** Walking Dead #1, Invincible #1, and other Image keys have many later printings; first-print markers (interior credits, UPC details) make the difference between a key and a common reprint.
- **Buy graded for high-value keys.** For four-figure books, insist on CGC, CBCS, or PGX slabs and confirm the cert against the grader's census — counterfeit slabs and label swaps exist.
- **Distinguish direct vs. newsstand.** On ASM #546 and similar issues, the newsstand variant commands a premium; check the UPC box.
- **Mind the grade cliff.** Modern keys concentrate value in CGC 9.8 and 9.9; a 9.6 can be worth a fraction of a 9.8 on the same book.
- **Track adaptation timing.** Demand for film/TV-linked keys swings with release cycles; buy into lulls, not hype peaks.

What matters less than the hype: chasing every variant cover. For most collectors, a clean first-print first appearance in high grade beats a stack of speculative variants.

## FAQ

**What makes a 2000s comic book valuable?**  
Value is driven by first appearances, low print runs, and cultural impact from adaptations. Condition is critical — most modern-age keys hold value in CGC 9.8 or higher, with raw copies often trading at a steep discount. Market demand also shifts with movie and TV announcements.

**Is The Walking Dead #1 still the best investment from the 2000s?**  
It remains the most valuable modern-age key from the decade, but its price has stabilized after the AMC series ended. A CGC 9.8 typically ranges from $3,000 to $6,000, while raw copies can be found for $1,000 or more. It’s a blue-chip collectible, but growth may be slower than for keys with upcoming screen adaptations.

**How do I verify I have a true first printing of a 2000s key?**  
Check the indicia on the first interior page for the printing number, and compare cover details — many 2000s keys have multiple printings with subtle differences. For high-value books like The Walking Dead #1 or NYX #3, a CGC grading label confirms the printing and condition. Online price guides and forums also list printing identifiers.

**Are raw copies of these comics worth buying?**  
Yes, if you’re a reader or budget-conscious collector, but expect lower resale value. Raw copies of top 2000s keys like NYX #3 can cost $100–$300, while a CGC 9.8 may be $400–$700. For investment, graded copies in 9.8 or higher are safer; raw books require careful inspection for defects that affect value.

**Which 2000s first appearances have the most growth potential?**  
Keys tied to upcoming live-action adaptations often see the biggest jumps. NYX #3 (first X-23) has room to grow with her Marvel Cinematic Universe debut, while books like Ultimate Fallout #4 (first Miles Morales) already command high prices. Smaller keys like Invincible #1 or Runaways #1 also have loyal fanbases and moderate upside.

**How do I sell a high-grade 2000s comic in 2027?**  
Auction houses like Heritage or ComicConnect work best for top-tier keys (CGC 9.8 or 9.9), especially if you have recent comps. For mid-range books, eBay or dedicated Facebook groups offer faster sales but lower fees. Always use tracked shipping and insurance for books over $500.

## Bottom Line

**The Walking Dead #1 (2003)** is the **Best Overall** 2000s comic — the decade's most valuable modern-age key, with a CGC 9.8 around **$3,000–$6,000** and a 9.9 at **$13,000**. For collectors who want a genuine first appearance with screen relevance at a friendlier price, **NYX #3 (2004)**, the first X-23, is the **Best Value** at **$400–$700** in CGC 9.8. Across the list, first-print verification and CGC grade are everything — buy verified slabs, confirm the printing, and let condition guide your money.

<!--pillar-weave-->
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- [The 10 Best Comic Books from the 1950s](/knowledge/co0066)
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- [The 10 Best Comic Books from the 1970s](/knowledge/co0044)

## Sources

- [Heritage Auctions — The Walking Dead #1 (2003) CGC 9.8](https://comics.ha.com/itm/modern-age-1980-present-/horror/walking-dead-1-image-2003-cgc-nm-mt-98-white-pages/a/7076-91229.s)
- [Heritage Auctions — Ultimate Spider-Man Price Guide](https://comics.ha.com/comic-title-index/ultimate-spider-man.s?id=7825)
- [Heritage Auctions — NYX #3 (2004) First X-23](https://comics.ha.com/itm/modern-age-1980-present-/nyx-3-marvel-2004-cgc-nm-mt-98-white-pages/a/122015-13311.s)
- [PriceCharting — Invincible #1 (2003)](https://www.pricecharting.com/game/comic-books-invincible-image/invincible-1-2003)
- [PriceCharting — Batman #608 (2002)](https://www.pricecharting.com/game/comic-books-batman/batman-608-2002)
- [GoCollect — NYX #3 Value Guide](https://gocollect.com/comic/nyx-3)
- [PriceCharting — Amazing Spider-Man #546 (2008)](https://www.pricecharting.com/game/comic-books-amazing-spider-man/amazing-spider-man-546-2008)

*The 10 best comic books from the 2000s review — 2000s comic books reviews, ratings, best modern comic books 2027, and a review of the top picks for collectors.*

**People also search for:** best comic books from the 2000s · top comic books from the 2000s · top rated comic books from the 2000s · top ranked comic books from the 2000s · highest rated comic books from the 2000s · comic books from the 2000s reviews

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Kory White

The 10 Best Comic Books from the 2000s

1. How We Ranked the Top 10

1. The Walking Dead #1 (2003) 🏆 BEST OVERALL

2. Ultimate Spider-Man #1 (2000)

3. NYX #3 (2004) — First X-23 💎 BEST VALUE

4. Invincible #1 (2003)

5. Batman #608 (2002) — Hush

6. Ultimate X-Men #1 (2001)

7. Amazing Spider-Man #546 (2008) — First Mr. Negative

8. Ultimate Fantastic Four #1 (2004)

9. The Walking Dead #19 (2005) — First Michonne

10. The Walking Dead #100 (2012-adjacent key) / Runaways #1 (2003)

Which One Is Right for You?

What to Look For

FAQ

Bottom Line

Related on PULSE

Sources

Two scores — Gate vs IQ